Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor
Fenghui Zhao, Chao Zhang, Qingtong Zhou, Kaini Hang, Xinyu Zou, Yan Chen, Fan Wu, Qidi Rao, Antao Dai, Wanchao Yin, Dandan Shen, Yan Zhang, Tian Xia, Raymond C. Stevens, H. Eric Xu, , Ming‐Wei Wang
The paper reports the cryo-EM structure of the human GIPR complexed with GIP and a Gs heterotrimer, revealing how GIP is recognized and activates the receptor.
eLife · Jul 13, 2021Peer-reviewedMolecular Biology