Wanchao Yin

Fine-tuning an intracellular allosteric pocket programs GPCR signaling bias

This study fine-tunes an intracellular allosteric pocket of NTSR1 to program GPCR signaling bias, revealing how ligand modifications alter transducer coupling and downstream signaling.

Molecular architecture of OXGR1 reveals evolutionary conserved mechanisms for metabolite surveillance

This study determines the cryo-EM structures of OXGR1 bound to metabolites, revealing conserved mechanisms for metabolite recognition and receptor activation.

Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors

The paper reports the structures of galanin bound to its receptors and G proteins, revealing the molecular basis for allosteric agonism and G protein subtype selectivity.

Structures of full-length glycoprotein hormone receptor signaling complexes

The paper reports cryo-EM structures of LHCGR in different activation states, revealing a push and pull mechanism of receptor activation and the role of an allosteric agonist.

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

The paper reports the cryo-EM structure of the human GIPR complexed with GIP and a Gs heterotrimer, revealing how GIP is recognized and activates the receptor.

Structural basis for repurposing a 100-years-old drug suramin for treating COVID-19

The paper discovers suramin as a potent inhibitor of SARS-CoV-2 RNA polymerase and provides its structural mechanism for repurposing in treating COVID-19.

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

This study reports the structure of SARS-CoV-2 RdRp with and without Remdesivir, showing how the drug inhibits viral RNA replication by terminating chain elongation.