Incongruent end structures of leading and lagging telomeres dictate the nature of end replication problem
Tiantian Ye, Qingqing Yuan, Shuheng Wu, Jinsong Zhao, Zhi-Jing Wu, Jiacheng Liu, Wei Wu, Jin‐Qiu Zhou
The paper investigates telomere end replication in yeast, showing that lagging strand telomeres have a 3' overhang while leading strand telomeres are blunt, with RNase H2 removing the last RNA primer.
bioRxiv · Feb 23, 2025 · PreprintMolecular Biology