Author

Shuheng Wu

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 2 Assay:DNA methylation· 2 Organism:Drosophila· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Wei WuiD· 2 shared Changwei ShaoiD· 1 shared Do‐Hwan LimiD· 1 shared Dongpeng WangiD· 1 shared Jiacheng LiuiD· 1 shared Jiayu CheniD· 1 shared Jin‐Qiu ZhouiD· 1 shared Jinsong ZhaoiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMolecular Biology

Wei WuORCID

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3 papers

Recent·Most cited

Incongruent end structures of leading and lagging telomeres dictate the nature of end replication problem

Tiantian Ye, Qingqing Yuan, Shuheng Wu, Jinsong Zhao, Zhi-Jing Wu, Jiacheng Liu, Wei Wu, Jin‐Qiu Zhou

The paper investigates telomere end replication in yeast, showing that lagging strand telomeres have a 3' overhang while leading strand telomeres are blunt, with RNase H2 removing the last RNA primer.

bioRxiv · Feb 23, 2025 · PreprintMolecular Biology

Tracking mobilization uncovers an evolutionarily conserved mechanism in suppressing transpositions during somatic development

Yi Ni Luo, Yu Liang, Shuheng Wu, Yazi Deng, Wei Wu, ZZ Zhao Zhang, Lu Wang

The paper identifies Cramp1 as an evolutionarily conserved factor that suppresses transposon mobilization during somatic development by initiating H1 transcription and promoting H3K36me2-established heterochromatin.

bioRxiv · Feb 7, 2025 · PreprintGenetics

Trading Genome Vulnerability for Stable Genetic Inheritance: Active Retrotransposons Help Maintain Pericentromeric Heterochromatin Required for Faithful Cell Division

Yajing Hao, Dongpeng Wang, Shuheng Wu, Xiao Li, Changwei Shao, Peng Zhang, Jiayu Chen, Do‐Hwan Lim, Xiang‐Dong Fu, Runsheng Chen, Shunmin He

The paper shows that active retrotransposons produce siRNAs that maintain pericentromeric heterochromatin, ensuring stable genetic inheritance in Drosophila cells.

Genome Research · Nov 1, 2020Peer-reviewedGenomics