Zhi-Jing Wu

Incongruent end structures of leading and lagging telomeres dictate the nature of end replication problem

The paper investigates telomere end replication in yeast, showing that lagging strand telomeres have a 3' overhang while leading strand telomeres are blunt, with RNase H2 removing the last RNA primer.

Elimination of subtelomeric repeat sequences exerts little effect on telomere essential functions in Saccharomyces cerevisiae

This study shows that deleting subtelomeric X- and Y-elements in yeast does not affect telomere length or silencing, but impacts telomere maintenance when telomerase is inactivated.