YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity
Haiyan Zhang, Xiao-Jing Luo, Wei Yang, Zhiying Wu, Zhicong Zhao, Xin Pei, Xue Zhang, Chonghao Chen, Josh Haipeng Lei, Qingxia Shi, Qi Zhao, Yanxing Chen, Wenwei Wu, Zhao-Lei Zeng, Huai‐Qiang Ju, , Jiajie Hou
This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.
Nature Communications · Nov 5, 2024Peer-reviewedImmunology