Chu‐Xia Deng

MVCBench evaluates drug molecular and gene representation methods for predicting drug-induced multimodal cell phenotypes using transcriptomic and imaging data.

This study shows SRSF3 is oncogenic in breast cancer and tumor-suppressive in liver cancer through context-dependent gene regulation.

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

This study identifies protein damage response (PDR) as a key mechanism in cancer drug resistance, showing that targeting PDR components can enhance drug efficacy in resistant cells.