Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice
Daniel Ferguson, Elise I. Gadson, Kathleen R. Markan, Jun Yoshino, Maxwell Lin, Mohammad Habibi, Snigdha Tiash, Xiaoxia Cui, Evguenia V. Kouranova, Edziu Franczak, Qiuyuan Guo, Jill Kealing, Terri Pietka, Kim H. H. Liss, John P. Thyfault, , Sandip Kumar Mukherjee
This study shows that overexpressing NAMPT in adipocytes protects against metabolic dysfunction in male obese mice but not females, via improved interorgan communication and extracellular vesicle effects.
bioRxiv · Sep 30, 2025 · PreprintPhysiology