Pharmacological rescue of mitochondrial dysfunction, neurite degeneration, and premature death of ALS and AD iPSC-derived neurons
Neelam Shahani, Rupkatha Banerjee, Courtney MacMullen, Neelam Sharma, Mohammad Habibi, Henry D. Wasserman, Nathaniel C. Noyes, Puhan Zhao, Bahaa Elgendy, M S Cameron, Thomas D. Bannister, Lamees Hegazy, Brian N. Finck, Ronald L. Davis
This study identifies Dipyridamole as a drug that rescues mitochondrial dysfunction and neuronal death in ALS and AD iPSC-derived neurons by enhancing mitochondrial pyruvate uptake.
bioRxiv · May 5, 2026 · PreprintNeuroscience