Author

R Doty

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Abigail L. D. TadeneviD· 1 shared Alejandro BarreraiD· 1 shared Alexander ThomsoniD· 1 shared Andrew S. AlleniD· 1 shared Boyao LiiD· 1 shared Brian Robert HoffmanniD· 1 shared Carol J. BultiD· 1 shared Courtney L. HattoniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Abigail L. D. TadenevORCID

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2 papers

Recent·Most cited

Modeling gene regulatory perturbations via deep learning from high-throughput reporter assays

Revathy Venukuttan, R Doty, Alexander Thomson, Yutian Chen, Boyao Li, Yuncheng Duan, Alejandro Barrera, Katherine Dura, Kuei-Yueh Ko, Hilmar Lapp, Timothy E. Reddy, Andrew S. Allen, William H. Majoros

The paper introduces BlueSTARR, a predictive modeling framework trained on whole-genome STARR-seq data to assess variant effects on regulatory functions, revealing purifying selection against loss-of-function and gain-of-function variants.

bioRxiv · Mar 31, 2026 · PreprintBioinformatics

Mouse models of NADK2 deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiology

G C Murray, Preeti Bais, Courtney L. Hatton, Abigail L. D. Tadenev, Brian Robert Hoffmann, Timothy J. Stodola, Kathryn H. Morelli, Samia L. Pratt, David G. Schroeder, R Doty, Oliver Fiehn, Simon W. M. John, Carol J. Bult, Gregory A. Cox, Robert W. Burgess

This study analyzes NADK2 deficiency in mouse models to identify metabolic and gene expression changes, revealing similarities and differences with another neurological disease model.

Human Molecular Genetics · Jul 7, 2022Peer-reviewedGenetics