Spatial Rewiring of Enterocyte Identity in Celiac Disease
Tal Barkai, Rachel Frieman-Sharabi, Keren Bahar Halpern, Roy Novoselsky, Yael Korem Kohanim, Sapir Shir, Ofra Golani, Inna Goliand, Yoseph Addadi, Merav Kedmi, Hadas Keren‐Shaul, Lena Prichislov, Anat Guz‐Mark, Hadassah Nissim, R Shamir, , Shalev Itzkovitz
This study uses spatial and single-cell transcriptomics to show that celiac disease alters enterocyte states by promoting aberrant zonal co-expression and metaplastic cells.
bioRxiv · Feb 17, 2026 · PreprintSystems Biology