Hadas Keren‐Shaul

The paper identifies persistent stromal reprogramming in mucosal healing of ulcerative colitis and links it to therapeutic response prediction.

Spatial transcriptomics of live healthy donor livers shows most hepatocyte genes are zonated, with key functions pericentrally shifted versus mouse, pig, boar and cow.

The paper uses spatial transcriptomics to analyze thyroid heterogeneity, identifying a damage-response thyrocyte state that balances with hormone-producing states across scales.

This study uses spatial transcriptomics and proteomics to analyze IDH-mutant gliomas, revealing distinct spatial organization patterns across tumor grades.

This study uses spatial and single-cell transcriptomics to show that celiac disease alters enterocyte states by promoting aberrant zonal co-expression and metaplastic cells.

This study quantifies senescence burden at the single-cell level across tissues in mice and human PBMCs, revealing tissue-specific ageing dynamics and senescence marker heterogeneity.

The paper examines circadian gene expression in microglia across health and Huntington's disease, finding disrupted rhythms in symptomatic mice.

This paper develops a transgene-free human post-implantation embryo model from genetically unmodified naive PSCs, recapitulating key developmental stages and extra-embryonic tissues.

The paper introduces DestVI, a method for multi-resolution spatial transcriptomics analysis that captures continuous cell state variation, and applies it to study inflammation in lymph nodes and tumors.

The paper identifies bi-fated tendon-to-bone attachment cells regulated by shared enhancers and KLF transcription factors, revealing how these cells integrate chondrocyte and tenocyte features.