Yael Korem Kohanim

A spatial transcriptomics atlas of live donors reveals unique zonation patterns in the healthy human liver

Spatial transcriptomics of live healthy donor livers shows most hepatocyte genes are zonated, with key functions pericentrally shifted versus mouse, pig, boar and cow.

A stress-function tradeoff organizes epithelial heterogeneity across spatial scales in the human thyroid

The paper uses spatial transcriptomics to analyze thyroid heterogeneity, identifying a damage-response thyrocyte state that balances with hormone-producing states across scales.

Spatial Rewiring of Enterocyte Identity in Celiac Disease

This study uses spatial and single-cell transcriptomics to show that celiac disease alters enterocyte states by promoting aberrant zonal co-expression and metaplastic cells.

Unifying regulatory motifs in endocrine circuits

This study identifies five classes of endocrine circuits in humans, revealing shared structural and regulatory principles across 43 hormone systems.

Tradeoffs in bacterial physiology determine the efficiency of antibiotic killing

The paper measures antibiotic-mediated bacterial death and finds death rate is linear with growth rate but varies with environmental stress.

Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans

The paper identifies three inheritance rules governing transgenerational small RNA responses in C. elegans and shows they predict developmental rate and stress resistance.

Human hormone seasonality

The paper analyzes health records to show seasonal patterns in human hormones, finding that effector hormones peak in winter-spring while upstream pituitary hormones peak in summer, suggesting a circannual clock mechanism.

A bacterial growth law out of steady-state

The paper derives and tests a growth law for bacterial upshifts, showing that post-shift growth rate is the geometric mean of pre-shift growth and saturating carbon growth, supported by experiments and theoretical analysis.