Author

R. A. Gladstone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 1

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Approach:statistical model· 4 Organism:human· 3 Organism:E. coli· 2 Assay:long-read sequencing· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. Corander· 4 shared O. Samuelsen· 3 shared P. J. Johnsen· 3 shared S. Arredondo-Alonso· 3 shared S. D. Bentley· 3 shared A. K. Pontinen· 2 shared A. K. Pöntinen· 2 shared G. Tonkin-Hill· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersMicrobiology

J. Corander

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Author profile →

6 papers

Recent·Most cited

Plasmid-driven strategies for clone success in Escherichia coli

S. Arredondo-Alonso, A. K. Pontinen, J. Gama, R. A. Gladstone, K. Harms, G. Tonkin-Hill, H. A. Thorpe, G. S. Simonsen, O. Samuelsen, P. J. Johnsen, J. Corander

The paper uses long-read sequencing to analyze plasmids and chromosomes in E. coli over two decades, revealing long-term plasmid-lineage associations and success strategies.

bioRxiv · Oct 14, 2023 · PreprintMicrobiology

Strong pathogen competition in neonatal gut colonisation

T. Mäklin, H. A. Thorpe, A. K. Pöntinen, R. A. Gladstone, Y. Shao, M. Pesonen, A. McNally, P. J. Johnsen, O. Samuelsen, T. D. Lawley, A. Honkela, J. Corander

This study quantifies strain-level colonisation dynamics of gut pathogens in neonates, finding strong competition and some synergies, and reveals pathogenic potential differences among ExPEC clones.

bioRxiv · Jun 19, 2022Microbiology

Robust analysis of prokaryotic pangenome gene gain and loss rates with Panstripe

G. Tonkin-Hill, R. A. Gladstone, A. K. Pontinen, S. Arredondo-Alonso, S. D. Bentley, J. Corander

The paper introduces Panstripe, a method to robustly analyze gene gain and loss rates in prokaryotic pangenomes, accounting for sampling bias and annotation errors.

bioRxiv · Apr 23, 2022Evolutionary Biology

A high-throughput multiplexing and selection strategy to complete bacterial genomes

S. Arredondo-Alonso, A. K. Pöntinen, F. Cleon, R. A. Gladstone, A. C. Schürch, P. J. Johnsen, O. Samuelsen, J. Corander

This paper evaluates a high-throughput multiplexing strategy using Oxford Nanopore Technologies to complete bacterial genomes, showing improved assembly contiguity and completeness.

bioRxiv · Jun 14, 2021Microbiology

A novel mosaic tetracycline resistance gene tet(S/M) detected in a multidrug-resistant pneumococcal CC230 lineage that underwent capsular switching in South Africa

S. W. Lo, R. A. Gladstone, A. J. van Tonder, M. du Plessis, J. E. Cornick, P. A. Hawkins, S. A. Madhi, S. A. Nzenze, R. Kandasamy, K. Ravikumar, N. Elmdaghri, B. Kwambana-Adams, S. C. G. Almeida, A. Skoczynska, E. Egorova, , A. von Gottberg

The paper identifies a novel tetracycline resistance gene tet(S/M) in a multidrug-resistant pneumococcal lineage in South Africa and links its spread to HIV treatment and vaccine implementation.

bioRxiv · Jul 30, 2019 · PreprintMicrobiology

Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae

D. W. Cleary, V. T. Devine, D. E. Morris, K. L. Osman, R. A. Gladstone, S. D. Bentley, S. N. Faust, S. C. Clarke

This study examines how the introduction of pneumococcal conjugate vaccine 13 affected the population genomics of non-typeable Haemophilus influenzae in children, showing increased carriage and lineage-specific associations with Streptococcus pneumoniae.

bioRxiv · Dec 4, 2017Microbiology