T. D. Lawley

Enterocloster clostridioformis induces host intestinal epithelial responses that protect against Salmonella infection

The paper identifies Enterocloster clostridioformis as a protective commensal bacterium that induces host intestinal epithelial responses to resist Salmonella infection.

Genomic and ecologic characteristics of the airway microbial-mucosal complex

The paper characterizes the genomic and ecological features of the airway microbial-mucosal complex, identifying novel bacteria and functional pathways linked to lung diseases.

Strong pathogen competition in neonatal gut colonisation

This study quantifies strain-level colonisation dynamics of gut pathogens in neonates, finding strong competition and some synergies, and reveals pathogenic potential differences among ExPEC clones.

Two microbiota subtypes identified in Irritable Bowel Syndrome with distinct responses to the low FODMAP diet

This paper identifies two IBS microbiota subtypes with distinct responses to the low FODMAP diet, showing that the pathogenic-like subtype responds better to dietary intervention.

Functional and taxonomic comparison of mouse and human gut microbiotas using extensive culturing and metagenomics

The paper compares mouse and human gut microbiotas using metagenomics and culturing to identify functional similarities and taxonomic differences.

Novel gut pathobionts confound results in a widely used mouse model of human inflammatory disease

The paper identifies two novel gut bacteria that influence disease variability in a mouse model of inflammatory bowel disease.

Host adaptation in gut Firmicutes is associated with sporulation loss and altered colonisation patterns

The paper shows that loss of sporulation in gut Firmicutes is linked to host adaptation, with non-sporulating bacteria being more abundant but less prevalent globally.

Massive expansion of human gut bacteriophage diversity

The paper introduces the Gut Phage Database (GPD), a large collection of gut bacteriophage genomes, and identifies widespread viral diversity and gene flow networks in the human gut.

Global genomic population structure of Clostridioides difficile

This study introduces EnteroBase, a database for C. difficile genomic data, showing it can identify related genomes with 89% consistency between cgMLST and SNPs.

Comprehensive genome analyses of Sellimonas intestinalis, a potential biomarker of homeostasis gut recovery

This study characterizes Sellimonas intestinalis using genome sequencing and comparative analysis, revealing its potential as a biomarker for gut homeostasis recovery.

Proteomic identification of Axc, a novel beta-lactamase with carbapenemase activity in a meropenem-resistant clinical isolate of Achromobacterxylosoxidans

The paper identifies Axc, a novel beta-lactamase with carbapenemase activity, in a meropenem-resistant Achromobacter xylosoxidans isolate using proteomics and confirms its role in resistance.