Author

K. L. Osman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. E. Cavell· 2 shared B. Hallis· 2 shared D. J. Harris· 2 shared D. Ngabo· 2 shared E. J. Penn· 2 shared J. Paterson· 2 shared K. A. Ryan· 2 shared K. E. Gooch· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

B. E. Cavell

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform

D. Bojkova, P. Reus, L. Panosch, M. Bechtel, T. Rothenburger, J. Kandler, A. Pfeiffer, J. U. Wagner, M. Shumliakivska, S. Dimmeler, R. Olmer, U. Martin, F. Vondran, T. Toptan, F. Rothweiler, , J. Cinatl

This study develops a phenotypic screening platform using caspase 3/7 activity to identify antiviral compounds against SARS-CoV-2, including novel candidates and combinations.

bioRxiv · Jul 17, 2022Pharmacology & Toxicology

Convalescence from prototype SARS-CoV-2 protects Syrian hamsters from disease caused by the Omicron variant

K. A. Ryan, R. J. Watson, K. R. Bewley, C. A. Burton, O. Carnell, B. E. Cavell, A. R. Challis, N. S. Coombes, K. Emery, R. Fell, S. A. Fotheringham, K. E. Gooch, K. Gowan, A. Handley, D. J. Harris, , Y. Hall

This study shows that prior infection with a prototype SARS-CoV-2 strain protects Syrian hamsters from Omicron-induced disease.

bioRxiv · Dec 24, 2021 · PreprintMicrobiology

Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge

K. A. Ryan, K. R. Bewley, S. A. Fotheringham, P. Brown, Y. Hall, A. C. Marriott, J. A. Tree, L. Allen, M. J. Aram, E. Brunt, K. R. Buttigieg, B. E. Cavell, D. P. Carter, R. Cobb, N. S. Coombes, , M Dennis

This study investigates the dose-dependent response of ferrets to SARS-CoV-2 infection, showing protection against re-challenge and mild clinical disease.

Nature Communications · Jan 4, 2021Peer-reviewedMicrobiology

Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae

D. W. Cleary, V. T. Devine, D. E. Morris, K. L. Osman, R. A. Gladstone, S. D. Bentley, S. N. Faust, S. C. Clarke

This study examines how the introduction of pneumococcal conjugate vaccine 13 affected the population genomics of non-typeable Haemophilus influenzae in children, showing increased carriage and lineage-specific associations with Streptococcus pneumoniae.

bioRxiv · Dec 4, 2017Microbiology