R. A. Mariuzza

Cooperative binding of TCR and CD4 to pMHC enhances TCR sensitivity

The paper shows CD4 enhances TCR sensitivity by forming trimolecular bonds with pMHC, which are stabilized by force and proximity.

Structural basis for recognition of two HLA-A2-restricted SARS-CoV-2 spike epitopes by public and private T cell receptors

The paper determines the structural basis for recognition of two SARS-CoV-2 spike epitopes by T cell receptors, revealing insights into epitope specificity and variation.