Author

R. Gowthaman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Assay:protein structure· 2 Approach:statistical model· 2 Assay:structural biology· 2 Organism:virus· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

B. G. Pierce· 3 shared J. D. Guest· 3 shared R. Yin· 3 shared A. K. Gupta· 1 shared A. Kolesnikov· 1 shared A. Shmelev· 1 shared D. K. Johnson· 1 shared D. Wu· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMicrobiology

B. G. Pierce

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Author profile →

4 papers

Recent·Most cited

Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry

N. Bai, Y. Adeshina, I. Bychkov, Y. Xia, R. Gowthaman, S. A. Miller, A. K. Gupta, D. K. Johnson, L. Lan, E. A. Golemis, P. B. Makhov, L. Xu, M. M. Pillai, Y. Boumber, J. Karanicolas

This paper designs inhibitors for Musashi proteins MSI1 and MSI2 by mimicking hotspot pharmacophores from protein-RNA complexes, showing specificity and activity in multiple assays.

bioRxiv · Jan 9, 2023 · PreprintBiochemistry

Structural basis for recognition of two HLA-A2-restricted SARS-CoV-2 spike epitopes by public and private T cell receptors

D. Wu, A. Kolesnikov, R. Yin, J. D. Guest, R. Gowthaman, A. Shmelev, Y. Serdyuk, G. A. Efimov, B. G. Pierce, R. A. Mariuzza

The paper determines the structural basis for recognition of two SARS-CoV-2 spike epitopes by T cell receptors, revealing insights into epitope specificity and variation.

bioRxiv · Jul 28, 2021Immunology

Structural and energetic profiling of SARS-CoV-2 antibody recognition and the impact of circulating variants

R. Yin, J. D. Guest, G. Taherzadeh, R. Gowthaman, I. Mittra, J. Quackenbush, B. G. Pierce

The paper maps antibody recognition of SARS-CoV-2 spike RBD using computational structural analysis and identifies antibodies effective against viral variants.

bioRxiv · Mar 21, 2021Microbiology

CoV3D: A database and resource for high resolution coronavirus protein structures

R. Gowthaman, J. D. Guest, R. Yin, J. Adolf-Bryfogle, W. R. Schief, B. G. Pierce

CoV3D provides a database of coronavirus protein structures, including spike glycoprotein complexes, for vaccine and therapeutic design.

bioRxiv · May 12, 2020Microbiology