Author

M. N. Rushdi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Zhu· 3 shared K. Li· 3 shared C. Ge· 2 shared H.-K. Choi· 2 shared A. H. K. Ashkezari· 1 shared A. M. Rosado· 1 shared A. Natarajan· 1 shared B. Kinney· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

C. Zhu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tumor microenvironments impair T cell receptor affinity and function

Z. Yuan, M. J. O'Melia, K. Li, J. Lyu, A. M. Rosado, V. E. Watson, A. H. K. Ashkezari, F. Zhou, V. Kansal, B. Kinney, S. Travaglino, L. O. Doudy, R. K. Noel, S. N. Lucas, S. L. Kong, , C. Zhu

This study shows that CD8+ T cells in the tumor microenvironment have reduced TCR-pMHC affinity and function, impairing their anti-tumor activity.

bioRxiv · Sep 11, 2022 · PreprintImmunology

Catch bond models may explain how force amplifies TCR signaling and antigen discrimination

H.-K. Choi, P. Cong, C. Ge, A. Natarajan, B. Liu, Y. Zhang, K. Li, M. N. Rushdi, W. Chen, J. Lou, M. Krogsgaard, C. Zhu

The paper develops models to explain how force affects TCR signaling and antigen discrimination by analyzing bond characteristics of TCR-pMHC interactions.

bioRxiv · Jan 17, 2022Biophysics

Cooperative binding of TCR and CD4 to pMHC enhances TCR sensitivity

M. N. Rushdi, V. Pan, K. Li, H.-K. Choi, S. Choi, J. Hong, F. Griffitts, P. Agnihotri, R. A. Mariuzza, Y. Ke, C. Zhu

The paper shows CD4 enhances TCR sensitivity by forming trimolecular bonds with pMHC, which are stabilized by force and proximity.

bioRxiv · Nov 22, 2021 · PreprintImmunology