P. C. Dorrestein

Spatial chemistry of citrus reveals molecules bactericidal to Candidatus Liberibacter asiaticus

This study uses spatial metabolomics to identify bactericidal compounds in citrus plants infected with Candidatus Liberibacter asiaticus, suggesting potential alternatives to antibiotics for HLB treatment.

Perinatal ampicillin administration modulates murine bile acid metabolism in vivo - an observational study

This study examines how ampicillin exposure via different routes affects bile acid metabolism in mice, finding significant changes in maternal bile acids and increased infant weight.

High Resolution Biological and Physical Sampling Reveals Expression of Domoic Acid Biosynthetic Genes at Frontal Zones

This study combines high-resolution physical and multi-omic sampling to identify DA biosynthetic gene expression in frontal zones of Monterey Bay during declining upwelling.

Comparative metabolomics and microbiome analysis of Ethanol vs. OMNImet/gene GUT fecal stabilization

This study compares the stability of fecal metabolome and microbiome using 95% ethanol and commercial kits under different storage conditions, finding comparable results to flash freezing.

Co-Occurrence Network Analysis Reveals The Alterations Of The Skin Microbiome And Metabolome In Atopic Dermatitis Patients

This study analyzes the skin microbiome and metabolome in healthy and atopic dermatitis patients to identify microbial and metabolic changes associated with the disease.

Trachymyrmex septentrionalis ants promote fungus garden hygiene using Trichoderma-derived metabolite cues

This paper identifies Trichoderma as a pathogen of fungus gardens and shows that peptaibols, its metabolites, trigger ant weeding behavior to maintain garden hygiene.

An untargeted metabolomics analysis of exogenous chemicals in human milk and transfer to the infant

This study uses untargeted metabolomics to analyze exogenous chemicals in human milk and finds they are present in newborn stool, indicating potential infant exposure through breastfeeding.

Non-Invasive Skin Sampling Detects Systemically Administered Drugs in Humans

This study shows that skin swabs combined with mass spectrometry can detect systemically administered drugs and their metabolites in humans.

Probiotic bacteria and bile acid profile are modulated by prebiotic diet and associate with facilitated diurnal clock/sleep realignment after chronic disruption of rhythms

This study shows that a prebiotic diet increases beneficial gut bacteria and bile acids, helping rats realign sleep and circadian rhythms after chronic disruption.

Convergent Evolution of Pain-Inducing Defensive Venom Components in Spitting Cobras

This study shows that three spitting cobra lineages independently evolved venom with increased pain-enhancing toxins, likely in response to hominin emergence.

Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas disease

The paper uses spatial metabolomics to identify localized metabolic changes in heart tissue of mice chronically infected with Trypanosoma cruzi, revealing distinct metabolic perturbations from parasite burden sites.

Metabolite profiling of experimental cutaneous leishmaniasis lesions demonstrates significant perturbations in tissue phospholipids

This study uses metabolomics to show significant changes in phospholipids in cutaneous leishmaniasis lesions and adjacent healthy tissue in mice.

Fungal-bacterial interaction selects for quorum sensing mutants and a metabolic shift towards the production of natural antifungal compounds

The paper shows that B. subtilis mutants with quorum-sensing mutations produce antifungal ketones instead of surfactins when interacting with the fungus S. terrestris.

Native Electrospray-based Metabolomics Enables the Detection of Metal-binding Compounds

The paper introduces a method to detect metal-binding compounds using native electrospray ionization mass spectrometry with metal infusion and molecular networking.

The Molecular and Microbial Microenvironments in Chronically Diseased Lungs

The paper generates 3D maps of microbiomes and metabolomes in cystic fibrosis lungs, revealing personalized and regiospecific chemical environments and microbial interactions.

Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids

The paper identifies novel conjugated bile acids produced by the microbiome in mice and humans using mass spectrometry and a murine 3D model.

MolNetEnhancer: enhanced molecular networks by integrating metabolome mining and annotation tools

MolNetEnhancer integrates metabolomics tools to improve chemical annotation and structural insight from mass spectrometry data.

Cutibacterium acnes antibiotic production shapes niche competition in the human skin microbiome

The paper identifies cutimycin, an antibiotic produced by Cutibacterium acnes, which reduces Staphylococcus colonization in human skin follicles.

Comprehensive mass spectrometry-guided plant specialized metabolite phenotyping reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae

The paper introduces a workflow for large-scale metabolite annotation in Rhamnaceae plants, revealing metabolic diversity and identifying clade-specific biosynthetic pathways.

Extracellular matrix components are required to protect Bacillus subtilis colonies from T6SS-dependent Pseudomonas invasion and modulate co-colonization of plant

This study shows that the extracellular matrix protects Bacillus subtilis from Pseudomonas invasion via T6SS and influences their co-colonization on plants.

Identification of the bacterial biosynthetic gene clusters of the oral microbiome illuminates the unexplored social language of bacteria during health and disease

This study identifies 4,915 bacterial biosynthetic gene clusters in the oral microbiome and finds differential representation of BGCs in health versus disease states like dental caries and periodontitis.

American Gut: an Open Platform for Citizen-Science Microbiome Research

The paper uses citizen-science data to analyze human stool microbiomes, revealing new insights into microbial diversity, metabolome composition, and associations with diet and health.

Preprint: Environmentally-Friendly Workflow Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking For the Discovery of Potent Anti-Viral Leads From Plants

This paper develops a supercritical fluid chromatography and tandem mass spectrometry workflow to isolate and identify antiviral compounds from plant extracts, discovering two potent antiviral diterpene esters.