Author

R. A. Totah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. J. Maldonato· 2 shared D. A. Russell· 2 shared A. D. Piscopio· 1 shared A. J. Perciaccante· 1 shared A. K. Tiwari· 1 shared A. V. Mitchell· 1 shared C. C. Lipsey· 1 shared C. M. Fitzsimmons· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

B. J. Maldonato

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Author profile →

3 papers

Recent·Most cited

METTL7A and METTL7B are responsible for S-thiol methyl transferase activity in liver

D. A. Russell, M. K. Chau, Y. Shi, B. J. Maldonato, R. A. Totah

This study identifies METTL7A and METTL7B as the enzymes responsible for thiol methyltransferase activity in liver microsomes, which methylates clinically relevant drugs.

bioRxiv · Oct 12, 2022 · PreprintBiochemistry

The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors

R. W. Robey, C. M. Fitzsimmons, W. M. Guiblet, W. J. E. Frye, J. Gonzalez Dalmasy, L. Wang, D. A. Russell, L. M. Huff, A. J. Perciaccante, F. Ali-Rahmani, C. C. Lipsey, H. M. Wade, A. V. Mitchell, S. S. Maligireddy, D. Terrero, , P. J. Batista

This study identifies METTL7A and METTL7B as methyltransferases that confer resistance to thiol-based HDAC inhibitors by modifying the drug's zinc-binding thiol.

bioRxiv · Oct 7, 2022Cancer Biology

Human METTL7B Encodes an Alkyl Thiol Methyltransferase that Methylates Hydrogen Sulfide

B. J. Maldonato, R. A. Totah

This study identifies METTL7B as an alkyl thiol methyltransferase that methylates hydrogen sulfide and other thiols, revealing its catalytic function and potential role in disease.

bioRxiv · Mar 6, 2020Pharmacology & Toxicology