Author

W. J. E. Frye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

M. M. Gottesman· 4 shared R. W. Robey· 4 shared A. J. Perciaccante· 2 shared D. Butcher· 2 shared E. F. Edmondson· 2 shared L. M. Huff· 2 shared L. M. Jenkins· 2 shared P. J. Batista· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersPharmacology & Toxicology

M. M. Gottesman

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4 papers

Recent·Most cited

The thiol methyltransferase activity of TMT1A (METTL7A) is conserved across species

J. M. Gonzalez Dalmasy, C. Fitzsimmons, W. J. E. Frye, A. J. Perciaccante, C. P. Jewell, L. M. Jenkins, P. J. Batista, R. W. Robey, M. M. Gottesman

This study shows that TMT1A's ability to methylate thiol-based HDAC inhibitors is conserved across species, suggesting its functional relevance in animal models.

bioRxiv · Nov 17, 2023Pharmacology & Toxicology

Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier

J. R. Thomas, W. J. E. Frye, R. W. Robey, A. C. Warner, D. Butcher, J. L. Matta, T. C. Morgan, E. F. Edmondson, P. B. Salazar, S. Ambudkar, M. M. Gottesman

The paper identifies Abcg2a as the functional homolog of human ABCG2 at the zebrafish blood-brain barrier, showing its substrate overlap and BBB localization.

bioRxiv · May 18, 2023Cell Biology

The Multidrug Resistance Transporter P-glycoprotein Confers Resistance to Ferroptosis Inducers

W. J. E. Frye, L. M. Huff, J. M. G. Dalmasy, P. Salazar, R. M. Carter, R. T. Gensler, D. Esposito, R. W. Robey, S. V. Ambudkar, M. M. Gottesman

This study shows that P-glycoprotein (P-gp) and ABCG2 confer resistance to ferroptosis inducers, and some inducers inhibit these transporters, suggesting potential drug-drug interactions.

bioRxiv · Feb 23, 2023Pharmacology & Toxicology

The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors

R. W. Robey, C. M. Fitzsimmons, W. M. Guiblet, W. J. E. Frye, J. Gonzalez Dalmasy, L. Wang, D. A. Russell, L. M. Huff, A. J. Perciaccante, F. Ali-Rahmani, C. C. Lipsey, H. M. Wade, A. V. Mitchell, S. S. Maligireddy, D. Terrero, , P. J. Batista

This study identifies METTL7A and METTL7B as methyltransferases that confer resistance to thiol-based HDAC inhibitors by modifying the drug's zinc-binding thiol.

bioRxiv · Oct 7, 2022Cancer Biology