Author

A. J. Perciaccante

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

L. M. Jenkins· 2 shared M. M. Gottesman· 2 shared P. J. Batista· 2 shared R. W. Robey· 2 shared W. J. E. Frye· 2 shared A. D. Piscopio· 1 shared A. K. Tiwari· 1 shared A. V. Mitchell· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPharmacology & Toxicology

L. M. Jenkins

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2 papers

Recent·Most cited

The thiol methyltransferase activity of TMT1A (METTL7A) is conserved across species

J. M. Gonzalez Dalmasy, C. Fitzsimmons, W. J. E. Frye, A. J. Perciaccante, C. P. Jewell, L. M. Jenkins, P. J. Batista, R. W. Robey, M. M. Gottesman

This study shows that TMT1A's ability to methylate thiol-based HDAC inhibitors is conserved across species, suggesting its functional relevance in animal models.

bioRxiv · Nov 17, 2023Pharmacology & Toxicology

The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors

R. W. Robey, C. M. Fitzsimmons, W. M. Guiblet, W. J. E. Frye, J. Gonzalez Dalmasy, L. Wang, D. A. Russell, L. M. Huff, A. J. Perciaccante, F. Ali-Rahmani, C. C. Lipsey, H. M. Wade, A. V. Mitchell, S. S. Maligireddy, D. Terrero, , P. J. Batista

This study identifies METTL7A and METTL7B as methyltransferases that confer resistance to thiol-based HDAC inhibitors by modifying the drug's zinc-binding thiol.

bioRxiv · Oct 7, 2022Cancer Biology