R. Bhargava

Identification of proteotoxic and proteoprotective bacteria that non-specifically affect proteins associated with neurodegenerative diseases

This study identifies bacteria that affect protein aggregation and toxicity in neurodegenerative diseases using C. elegans models.

Spatial molecular profiling of mixed invasive ductal-lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations

This study uses spatial molecular profiling to show that mixed invasive ductal-lobular breast cancers have distinct molecular subtypes, oncogenic signatures, and mutations in different tumor regions, leading to prognostic uncertainty and therapeutic challenges.

Intermediate antiparallel beta structure in amyloid plaques revealed by infrared spectroscopic imaging

The paper uses infrared spectroscopic imaging to show that amyloid plaques in Alzheimer's disease contain antiparallel beta-sheet structures, linking in vitro findings to in vivo pathology.

Exome-Capture RNA-Sequencing Of Decade-Old Breast Cancers And Matched Decalcified Bone Metastases Identifies Clinically Actionable Targets

This study uses exome-capture RNA-sequencing on decade-old breast cancer specimens and matched bone metastases to identify clinically actionable gene expression changes in metastatic progression.