J. K. Kolls

The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection

This study examines how SIV-induced immunodeficiency affects SARS-CoV-2 infection in macaques, finding that while immune responses are impaired, viral kinetics and evolution remain unchanged.

Optimization of host cell-compatible, antimicrobial peptides effective against biofilms and clinical isolates of drug-resistant bacteria.

This study optimizes antimicrobial peptides to enhance activity against drug-resistant bacteria and biofilms while reducing cytotoxicity.

INSULIN-LIKE GROWTH FACTOR I REDUCES CORONARY ATHEROSCLEROSIS IN PIGS WITH FAMILIAL HYPERCHOLESTEROLEMIA

This study shows that IGF-1 reduces coronary atherosclerosis and promotes stable plaque features in FH pigs, with spatial transcriptomics revealing potential mechanistic insights.

Epithelial Plasticity and Innate Immune Activation Promote Lung Tissue Remodeling following Respiratory Viral Infection.

This study shows that epithelial plasticity and innate immune activation contribute to lung tissue remodeling after viral infection, protecting against mortality but causing long-term lung dysfunction.

Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast cancer recurrences

This study analyzes acquired mutations and transcriptional changes in long-term estrogen-deprived breast cancer recurrences, identifying common genetic and expression alterations associated with endocrine resistance.

Exome-Capture RNA-Sequencing Of Decade-Old Breast Cancers And Matched Decalcified Bone Metastases Identifies Clinically Actionable Targets

This study uses exome-capture RNA-sequencing on decade-old breast cancer specimens and matched bone metastases to identify clinically actionable gene expression changes in metastatic progression.