Author

R. Bruzzone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. K. P. Mok· 3 shared H. Lv· 3 shared N. C. Wu· 3 shared W. Liang· 3 shared B. Vanhove· 2 shared C. Ciron· 2 shared C. K. Mok· 2 shared E. Lheriteau· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

C. K. P. Mok

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Differential antigenic imprinting effects between influenza H1N1 hemagglutinin and neuraminidase in a mouse model

H. Lv, Q. W. Teo, C.-C. D. Lee, W. Liang, D. Choi, K. J. Mao, R. Bruzzone, I. A. Wilson, N. C. Wu, C. K. Mok

This study examines how immune history affects antibody responses to influenza H1N1 hemagglutinin and neuraminidase in mice, finding that HA responses are more restricted by prior infection than NA responses.

bioRxiv · Apr 17, 2024Immunology

Age-related seroprevalence trajectories of seasonal coronaviruses in children

Y. Luo, H. Lv, S. Zhao, Y. Sun, C. Liu, C. Chen, W. Liang, K.-o. Kwok, Q. W. Teo, R. T. So, Y. Lin, Y. Deng, B. Li, Z. Dai, J. Zhu, , X. Mu

This study examines age-related seroprevalence of four seasonal coronaviruses in children and postpartum women, showing waning passive immunity and resurgence of IgGs with age.

bioRxiv · Jul 26, 2022 · PreprintImmunology

Egg-adaptation pathway of human influenza H3N2 virus is contingent on natural evolution

W. Liang, T. J. C. Tan, Y. Wang, H. Lv, Y. Sun, R. Bruzzone, C. K. P. Mok, N. C. Wu

The paper shows that natural mutations in human H3N2 HA influence the egg-adaptation pathway, affecting mutation emergence during vaccine production.

bioRxiv · Jan 31, 2022 · PreprintMicrobiology

XAV-19, a swine glyco-humanized polyclonal antibody against SARS-CoV-2 Spike receptor-binding domain, targets multiple epitopes and broadly neutralizes variants.

B. Vanhove, S. S. Marot, R. So, B. Gaborit, G. Evanno, I. Malet, G. Lafrogne, E. Mevel, C. Ciron, P.-J. Royer, E. Lheriteau, F. Raffi, R. Bruzzone, C. K. P. Mok, O. Duvaux, , V. Calvez

XAV-19, a swine glyco-humanized polyclonal antibody against SARS-CoV-2 Spike RBD, neutralizes multiple variants by targeting multiple epitopes and shows potential in clinical trials.

bioRxiv · Apr 2, 2021Immunology

High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2

B. Vanhove, O. Duvaux, J. Rousse, P.-J. Royer, G. Evanno, C. Ciron, E. Lheriteau, L. Vacher, N. Gervois, R. Oger, Y. Jacques, S. Conchon, A. Salama, R. Duchi, I. Lagutina, , J.-P. Soulillou

This paper describes the development of glyco-humanized swine polyclonal antibodies (GH-pAb) that neutralize SARS-CoV-2 with high potency and safety, and suggests clinical evaluation of the antibody XAV-19.

bioRxiv · Jul 25, 2020Immunology

Activation of Src-family kinases orchestrate secretion of flaviviruses by targeting mature progeny virions to secretory autophagosomes

M. Y. Li, T. S. Naik, L. Y. L. Siu, O. Acuto, E. Spooner, P. Wang, X. Yang, Y. Lin, R. Bruzzone, J. Ashour, S. Sanyal

This study identifies Lyn-dependent secretory autophagosomes as a novel pathway for flavivirus secretion, enabling evasion of antibodies and tissue tropism.

bioRxiv · Jan 12, 2020 · PreprintMicrobiology