Author

N. Kapel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Oliver· 2 shared A. Quinn· 2 shared A. Ruzin· 2 shared B. Britto Xavier· 2 shared C. Lopez-Causape· 2 shared C. MacLean· 2 shared C. Recanatini· 2 shared J. Diaz Caballero· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersEvolutionary Biology

A. Oliver

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Polyclonal pathogen populations accelerate the evolution of antibiotic resistance in patients

J. Diaz Caballero, R. M. Wheatley, N. Kapel, C. Lopez-Causape, T. Van der Schalk, A. Quinn, C. Recanatini, B. Britto Xavier, L. Timbermont, J. Kluytmans, A. Ruzin, M. Esser, S. Malhotra-Kumar, A. Oliver, R. C. MacLean, WP3A working group

Antibiotic resistance evolves quickly in patients colonized by polyclonal pathogen populations.

bioRxiv · Dec 10, 2021 · PreprintEvolutionary Biology

Localized hypermutation drives the evolution of unstable colistin resistance in small populations of Pseudomonas aeruginosa

N. Kapel, J. F. Diaz Caballero, C. MacLean

The paper investigates how colistin resistance evolves in Pseudomonas aeruginosa populations, finding localized hypermutation in pmrB and evidence of phenotypic plasticity.

bioRxiv · Aug 10, 2021 · PreprintMicrobiology

Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota that Protects from Metabolic Diseases

E. Lecuyer, T. Le Roy, A. Gestin, A. Lacombe, C. Philippe, M. Ponnaiah, J. B. Hure, M. Fradet, F. Chou, S. Boudebbouze, T. Huby, E. Gautier, M. Rhimi, E. Maguin, N. Kapel, , P. Lesnik

This study shows that tolerogenic dendritic cells promote a gut microbiota that prevents metabolic diseases by enhancing butyrate production and reducing inflammation.

bioRxiv · Oct 22, 2020Immunology

Rapid evolution drives the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection

R. Wheatley, J. Diaz Caballero, N. Kapel, A. Quinn, E. del Barrio-Tofino, C. Lopez-Causape, J. Hedge, G. Torrens, T. Van der Schalk, B. Britto Xavier, F. Fernandez-Cuenca, A. Arenzana, C. Recanatini, L. Timbermont, F. Sifakis, , C. MacLean

The paper tracks the rapid evolution of carbapenem resistance in P. aeruginosa during an acute infection, showing resistance rise and fall due to antibiotic treatment.

bioRxiv · Aug 10, 2020Evolutionary Biology