Author

A. Ruzin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Bermingham· 2 shared A. Frommlet· 2 shared A. Lingel· 2 shared A. O. Frank· 2 shared A. Oliver· 2 shared A. Quinn· 2 shared B. Benton· 2 shared B. Britto Xavier· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

A. Bermingham

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Polyclonal pathogen populations accelerate the evolution of antibiotic resistance in patients

J. Diaz Caballero, R. M. Wheatley, N. Kapel, C. Lopez-Causape, T. Van der Schalk, A. Quinn, C. Recanatini, B. Britto Xavier, L. Timbermont, J. Kluytmans, A. Ruzin, M. Esser, S. Malhotra-Kumar, A. Oliver, R. C. MacLean, WP3A working group

Antibiotic resistance evolves quickly in patients colonized by polyclonal pathogen populations.

bioRxiv · Dec 10, 2021 · PreprintEvolutionary Biology

Rapid evolution drives the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection

R. Wheatley, J. Diaz Caballero, N. Kapel, A. Quinn, E. del Barrio-Tofino, C. Lopez-Causape, J. Hedge, G. Torrens, T. Van der Schalk, B. Britto Xavier, F. Fernandez-Cuenca, A. Arenzana, C. Recanatini, L. Timbermont, F. Sifakis, , C. MacLean

The paper tracks the rapid evolution of carbapenem resistance in P. aeruginosa during an acute infection, showing resistance rise and fall due to antibiotic treatment.

bioRxiv · Aug 10, 2020Evolutionary Biology

Two distinct mechanisms of small molecule inhibition of LpxA acyltransferase essential for lipopolysaccharide biosynthesis

W. Han, X. Ma, C. J. Balibar, C. M. Baxter Rath, B. Benton, A. Bermingham, F. Casey, B. Chie-Leon, M.-K. Cho, A. O. Frank, A. Frommlet, C.-M. Ho, P. S. Lee, M. Li, A. Lingel, , T. Uehara

The paper identifies two distinct mechanisms by which small molecules inhibit LpxA acyltransferase, a key enzyme in lipopolysaccharide biosynthesis.

bioRxiv · Dec 17, 2019 · PreprintBiochemistry

Two distinct mechanisms of small molecule inhibition of LpxA acyltransferase essential for lipopolysaccharide biosynthesis

W. Han, X. Ma, C. J. Balibar, C. M. Baxter Rath, B. Benton, A. Bermingham, F. Casey, B. Chi-Leon, M.-K. Cho, A. O. Frank, A. Frommlet, C.-M. Ho, P. S. Lee, M. Li, A. Lingel, , T. Uehara

This study identifies two small-molecule inhibitors of LpxA, revealing distinct inhibition mechanisms and highlighting compound 2's improved properties for antibacterial development.

bioRxiv · Dec 14, 2019 · PreprintBiochemistry