Author

R. Creutznacher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:protein structure· 2 Assay:cryo-EM· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Mallagaray· 3 shared C. Uetrecht· 3 shared T. Peters· 3 shared H. Yan· 2 shared J. Duelfer· 2 shared S. Taube· 2 shared B.-J. Bosch· 1 shared C. Caleman· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiophysics

A. Mallagaray

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MicrobiologybioRxivApr 20, 2023

Sialoglycan binding triggers spike opening in a human coronavirus

M. F. Pronker, R. Creutznacher, I. Drulyte…·D. L. Hurdiss

This study shows that sialoglycan binding triggers the opening of the spike protein in the human coronavirus HKU1 through allosteric inter-domain cross-talk.

DOI 10.1038/s41586-023-06599-z

humancryo-EM

𝕏 PostBluesky

BiophysicsbioRxivMay 1, 2021

Protein secondary structure affects glycan clustering in native mass spectrometry

H. Yan, J. Lockhauserbäumer, G. P. Szekeres…·C. Uetrecht

The paper investigates how protein secondary structure affects glycan clustering in native mass spectrometry, finding that β-sheet content strongly influences clustering behavior.

DOI 10.3390/life11060554

proteomicsexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivFeb 27, 2021

Murine norovirus capsid plasticity - Glycochenodeoxycholic acid stabilizes P domain dimers and triggers escape from antibody recognition

R. Creutznacher, T. Maass, J. Duelfer…·S. Taube

This paper investigates how GCDCA stabilizes MNV P-domain dimers, leading to structural changes that enable immune escape by preventing antibody recognition.

DOI 10.1038/s42003-022-03497-4

mouseprotein structure

𝕏 PostBluesky

BiophysicsbioRxivOct 7, 2020

Glycan-induced protein dynamics in human norovirus P dimers depend on virus strain and deamidation status

J. Duelfer, H. Yan, M. N. Brodmerkel…·C. Uetrecht

This study uses HDX-MS to analyze glycan-induced structural dynamics in norovirus P dimers across strains and deamidation states, revealing strain- and deamidation-dependent changes in protein flexibility and solvent exposure.

DOI 10.3390/molecules26082125

humanprotein structure

𝕏 PostBluesky