Author

B.-J. Bosch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

F. J. M. van Kuppeveld· 4 shared W. Li· 4 shared C. Wang· 3 shared D. Drabek· 2 shared F. Grosveld· 2 shared R. J. de Groot· 2 shared R. van Haperen· 2 shared Y. Lang· 2 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersMicrobiology

F. J. M. van Kuppeveld

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Sialoglycan binding triggers spike opening in a human coronavirus

M. F. Pronker, R. Creutznacher, I. Drulyte, R. J. G. Hulswit, Z. Li, F. J. M. van Kuppeveld, J. Snijder, Y. Lang, B.-J. Bosch, G.-J. Boons, M. Frank, R. J. de Groot, D. L. Hurdiss

This study shows that sialoglycan binding triggers the opening of the spike protein in the human coronavirus HKU1 through allosteric inter-domain cross-talk.

bioRxiv · Apr 20, 2023Microbiology

Structural basis for broad coronavirus neutralization

M. Sauer, Y.-J. Park, M. A. Tortorici, A. C. Walls, L. Homad, O. Acton, J. E. Bowen, C. Wang, X. Xiong, W. de van der Schueren, J. Quispe, B.-J. Bosch, B. G. Hoffstrom, A. T. McGuire, D. Veesler

This study identifies a monoclonal antibody that broadly neutralizes multiple beta-coronaviruses by targeting a conserved epitope, providing a structural basis for designing pan-coronavirus vaccines.

bioRxiv · Dec 29, 2020Biochemistry

RAPPID: a platform of ratiometric bioluminescent sensors for homogeneous immunoassays

Y. Ni, B. J. H. M. Rosier, E. A. van Aalen, E. T. L. Hanckmann, L. Biewenga, A.-M. Makri Pistikou, B. Timmermans, C. Vu, S. Roos, R. Arts, W. Li, T. F. A. de Greef, F. J. M. van Kuppeveld, B.-J. Bosch, M. Merkx

RAPPID is a homogeneous immunoassay platform using ratiometric bioluminescent sensors for direct in-sample calibration and quantitative detection of biomarkers.

bioRxiv · Oct 31, 2020 · PreprintBioengineering

Isolation of cross-reactive monoclonal antibodies against divergent human coronaviruses that delineate a conserved and vulnerable site on the spike protein

C. Wang, R. van Haperen, J. Gutierrez-Alvarez, W. Li, N. Okba, I. Albulescu, I. Widjaja, B. van Dieren, R. Fernandez-Delgado, I. Sola, D. Hurdiss, O. Daramola, F. Grosveld, F. van Kuppeveld, B. Haagmans, , B.-J. Bosch

This study isolates two cross-reactive monoclonal antibodies against multiple Betacoronaviruses, identifying a conserved vulnerable site on the spike protein.

bioRxiv · Oct 20, 2020 · PreprintMicrobiology

Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity

Y. Lang, W. Li, Z. Li, D. Koerhuis, A. C. S. van den Burg, E. Rozemuller, B.-J. Bosch, F. J. M. van Kuppeveld, G.-J. P. H. Boons, E. G. Huizinga, H. M. van der Schaar, R. J. de Groot

The paper shows that S and HE proteins co-evolve to balance attachment and release in coronaviruses, with functional interdependence observed in OC43 and HKU1.

Proceedings of the National Academy of Sciences · Sep 29, 2020Peer-reviewedMicrobiology

A human monoclonal 1 antibody blocking SARS-CoV-2 infection

C. Wang, W. Li, D. Drabek, N. M. A. Okba, R. van Haperen, A. D. M. E. Osterhaus, F. J. M. van Kuppeveld, B. L. Haagmans, F. Grosveld, B.-J. Bosch

This paper reports a human monoclonal antibody that neutralizes SARS-CoV-2 and SARS-CoV, targeting a shared epitope for potential prevention and treatment of COVID-19.

bioRxiv · Mar 11, 2020Microbiology