Author

M. F. Pronker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. Snijder· 5 shared W. Peng· 3 shared D. L. Hurdiss· 2 shared F. J. M. van Kuppeveld· 2 shared I. Drulyte· 2 shared R. J. de Groot· 2 shared Y. Lang· 2 shared A. D. Parvate· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersBiochemistry

J. Snijder

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Author profile →

5 papers

Recent·Most cited

Reverse engineering the anti-MUC1 hybridoma antibody 139H2 by mass spectrometry-based de novo sequencing

W. Peng, K. C. A. P. Giesbers, M. Siborova, J. W. Beugelink, M. F. Pronker, D. Schulte, J. Hilkens, B. J. C. Janssen, K. Strijbis, J. Snijder

This paper reverse engineers the anti-MUC1 hybridoma antibody 139H2 using mass spectrometry-based sequencing and validates its properties through various assays.

bioRxiv · Jul 5, 2023 · PreprintBiochemistry

Sialoglycan binding triggers spike opening in a human coronavirus

M. F. Pronker, R. Creutznacher, I. Drulyte, R. J. G. Hulswit, Z. Li, F. J. M. van Kuppeveld, J. Snijder, Y. Lang, B.-J. Bosch, G.-J. Boons, M. Frank, R. J. de Groot, D. L. Hurdiss

This study shows that sialoglycan binding triggers the opening of the spike protein in the human coronavirus HKU1 through allosteric inter-domain cross-talk.

bioRxiv · Apr 20, 2023Microbiology

Glycan shield of the ebolavirus envelope glycoprotein GP

W. Peng, V. Rayaprolu, A. D. Parvate, M. F. Pronker, S. Hui, D. Parekh, K. Shaffer, X. Yu, E. O. Saphire, J. Snijder

This study profiles the site-specific glycosylation patterns of ebolavirus GP using mass spectrometry, revealing complex N-, O-, and C-linked glycans that contribute to the glycan shield and restrict antibody neutralization.

bioRxiv · Feb 7, 2022Biochemistry

Mass spectrometry-based sequencing of the anti-FLAG-M2 antibody using multiple proteases and a dual fragmentation scheme

W. Peng, M. F. Pronker, J. Snijder

This paper introduces a method for de novo sequencing of monoclonal antibodies using multiple proteases and dual fragmentation, achieving high accuracy in sequence coverage.

bioRxiv · Jan 7, 2021Biochemistry

Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

D. L. Hurdiss, I. Drulyte, Y. Lang, T. M. Shamorkina, M. F. Pronker, F. J. M. van Kuppeveld, J. Snijder, R. J. de Groot

The paper presents the cryo-EM structure of HKU1 HE, revealing structural changes due to prolonged human circulation, including a truncated lectin domain and intact esterase domain.

Nature Communications · Sep 16, 2020Peer-reviewedMicrobiology