Author

R. D. Hellinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Ramos· 1 shared A. Regev· 1 shared C. E. Koch· 1 shared C. Pok· 1 shared D. Goulet· 1 shared F. Gao· 1 shared H. L. O'Brien· 1 shared J. Froese· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Ramos

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Compounds derived from N,N-dimethyldithiocarbamate are effective copper-dependent antimicrobials against Streptococcus pneumoniae

M. D. L. Johnson, S. V. Menghani, Y. Sanchez-Rosario, C. Pok, R. Liu, F. Gao, H. L. O'Brien, M. Neubert, K. Ochoa, R. D. Hellinger, W. Wang

The paper develops and tests novel DMDC-derived compounds as copper-dependent antimicrobials against Streptococcus pneumoniae, showing effectiveness in vitro and in vivo.

bioRxiv · Sep 23, 2022 · PreprintMicrobiology

Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening.

A. Ramos, C. E. Koch, Y. Liu, R. D. Hellinger, T. Kyung, K. L. Abbott, J. Froese, D. Goulet, K. S. Gordon, R. C. Larson, J. G. Doench, A. Regev, M. G. Vander Heiden, M. V. Maus, M. E. Birnbaum, M. Hemann

This study identifies leukemia-intrinsic resistance mechanisms to CAR-T therapy through in vivo CRISPR screening in a murine B-ALL model, revealing IFNγ/JAK/STAT and antigen processing pathways as key mediators.

bioRxiv · Feb 15, 2022 · PreprintCancer Biology