Author

J. Froese

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

F. Gude· 2 shared K. Ehring· 2 shared K. Grobe· 2 shared A. Ramos· 1 shared A. Regev· 1 shared C. E. Koch· 1 shared D. Goulet· 1 shared D. Manikowski· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

F. Gude

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins

K. Ehring, S. F. Ehlers, J. Froese, F. Gude, J. Puschmann, K. Grobe

This study shows that Dispatched (Disp) mediates the shedding and transfer of cholesterol-modified Sonic hedgehog (Shh) to high-density lipoproteins (HDL), with HDL-associated Shh being highly bioactive.

bioRxiv · Feb 8, 2023Cell Biology

Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening.

A. Ramos, C. E. Koch, Y. Liu, R. D. Hellinger, T. Kyung, K. L. Abbott, J. Froese, D. Goulet, K. S. Gordon, R. C. Larson, J. G. Doench, A. Regev, M. G. Vander Heiden, M. V. Maus, M. E. Birnbaum, M. Hemann

This study identifies leukemia-intrinsic resistance mechanisms to CAR-T therapy through in vivo CRISPR screening in a murine B-ALL model, revealing IFNγ/JAK/STAT and antigen processing pathways as key mediators.

bioRxiv · Feb 15, 2022 · PreprintCancer Biology

Conserved cholesterol-related activities of Dispatched drive Sonic hedgehog shedding from the cell membrane

K. Grobe, K. Ehring, D. Manikowski, J. Froese, P. Jakobs, F. Gude, U. Rescher, J. Goretzko

This study shows that Dispatched (Disp) facilitates cholesterol-dependent ectodomain shedding of Sonic hedgehog (Shh) ligand, and that this process is rescued by cholesterol removal or overexpression of Disp or Patched.

bioRxiv · Oct 19, 2020Cell Biology