Author

T. Kyung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Assay:CRISPR screen· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

K. S. Gordon· 3 shared M. E. Birnbaum· 3 shared A. Ramos· 2 shared D. J. Irvine· 2 shared P. V. Holec· 2 shared Y. Liu· 2 shared A. Q. Zhang· 1 shared A. Regev· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersImmunology

K. S. Gordon

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification of highly cross-reactive mimotopes for a public T cell response in murine melanoma

B. E. Grace, C. M. Backlund, D. M. Morgan, B. H. Kang, N. K. Singh, B. D. Huisman, C. G. Rappazzo, K. D. Moynihan, L. Maiorino, C. S. Dobson, T. Kyung, K. S. Gordon, P. V. Holec, O. C. T. Mbah, D. Garafola, , M. E. Birnbaum

The paper identifies a dominant tumor-associated antigen in murine melanoma and shows that engineered mimotopes can induce cross-reactive T cell responses.

bioRxiv · Feb 28, 2022Immunology

Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening.

A. Ramos, C. E. Koch, Y. Liu, R. D. Hellinger, T. Kyung, K. L. Abbott, J. Froese, D. Goulet, K. S. Gordon, R. C. Larson, J. G. Doench, A. Regev, M. G. Vander Heiden, M. V. Maus, M. E. Birnbaum, M. Hemann

This study identifies leukemia-intrinsic resistance mechanisms to CAR-T therapy through in vivo CRISPR screening in a murine B-ALL model, revealing IFNγ/JAK/STAT and antigen processing pathways as key mediators.

bioRxiv · Feb 15, 2022 · PreprintCancer Biology

CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptors

T. Kyung, K. S. Gordon, C. R. Perez, P. V. Holec, A. Ramos, A. Q. Zhang, Y. Liu, C. Koch, A. Starchenko, B. Joughin, D. A. Lauffenburger, D. J. Irvine, M. T. Hemann, M. E. Birnbaum

The paper develops a library-based platform to identify optimized chimeric antigen receptors (CARs) with improved anti-tumor functions through high-throughput screening of diverse signaling domains.

bioRxiv · Jul 9, 2021Immunology