Author

R. Huguet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. ElSohly· 1 shared B. Furtwängler· 1 shared B. T. Porse· 1 shared C. Mullen· 1 shared C. Tsai· 1 shared D. DiCara· 1 shared D. Lopez-Ferrer· 1 shared E. M. Schoof· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. ElSohly

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Author profile →

3 papers

Recent·Most cited

Exposing the molecular heterogeneity of glycosylated biotherapeutics

L. F. Schachner, C. Mullen, W. Phung, J. D. Hinkle, M. I. Beardsley, T. Bentley, P. Day, C. Tsai, S. Sukumaran, T. Baginski, D. DiCara, N. Agard, M. Masureel, J. Gober, A. ElSohly, , W. Sandoval

This paper introduces a new method for analyzing glycoform heterogeneity in biotherapeutics using mass spectrometry and bioinformatics, showing its effectiveness in measuring proteoform diversity and correlating glycoform sub-populations with pharmacological properties.

bioRxiv · May 10, 2023Biochemistry

Real-Time Search Assisted Acquisition on a Tribrid Mass Spectrometer Improves Coverage in Multiplexed Single-Cell Proteomics

B. Furtwängler, N. Üresin, K. Motamedchaboki, R. Huguet, D. Lopez-Ferrer, V. Zabrouskov, B. T. Porse, E. M. Schoof

The paper introduces RETICLE, a new acquisition strategy for multiplexed single-cell proteomics that improves proteome coverage and quantitative accuracy using real-time search and SPS-MS3 on a Tribrid mass spectrometer.

bioRxiv · Aug 16, 2021Biochemistry

Direct Measurement of Light and Heavy Antibody Chains Using Differential Ion Mobility Spectrometry and Middle-Down Mass Spectrometry

R. D. Melani, K. Srzentic, V. R. Gerbasi, J. P. McGee, R. Huguet, L. Fornelli, N. L. Kelleher

This paper introduces a rapid FAIMS tandem MS method for characterizing monoclonal antibody light and heavy chains, reducing analysis time by 40-60% compared to LC-MS/MS.

bioRxiv · Jul 5, 2019Biochemistry