Combined blockade of VEGF, Angiopoietin-2, and PD1 reprograms glioblastoma endothelial cells into quasi-antigen-presenting cells
Z. Amoozgar, J. Ren, N. Wang, T. P. Uccello, P. Andersson, G. Ferraro, S. Rajan, P. Lei, S. Subudhi, K. Kawaguchi, R. E. Tay, I. L. Gomes Dos Santos, P. Huang, H.-J. Kim, D. Fukumura, R. Jain
This study shows that blocking VEGF, Ang2, and PD1 reprograms GBM endothelial cells into quasi-antigen-presenting cells, enhancing anti-tumor responses and controlling edema.
bioRxiv · Sep 3, 2022 · PreprintCancer Biology