K. Kawaguchi

Homeotic and non-homeotic patterns in the tetrapod vertebral formula

The paper analyzes vertebral formulae across tetrapods to identify homeotic and non-homeotic patterns, revealing unexpected balances and correlations with Hox gene clusters.

Low albumin status accompanies multi-layered immunosuppressive phenotypes in metastatic breast cancer patients

The paper investigates the association between low albumin levels and immunosuppressive phenotypes in metastatic breast cancer patients using transcriptomic and metabolomic data.

Selective elimination of CD169+ macrophages in lymph nodes invaded by breast cancers

This study shows metastasized breast cancer cells eliminate CD169+ macrophages from lymph nodes, impairing anti-cancer immunity.

mRNA vaccine induces protective immunity against the type III secretory virulence of Pseudomonas aeruginosa

This study develops an mRNA vaccine targeting Pseudomonas aeruginosa's type III secretion system, showing improved mouse survival and reduced lung bacterial load after challenge.

Senescence triggers intracellular acidification and lysosomal alkalinization via ATP6AP2 attenuation in breast cancer cells

This study shows that ATP6AP2 downregulation in senescent breast cancer cells causes pH dysregulation, impairing lysosome function and altering immune responses.

Serum amyloid alpha 1-2 are not required for systemic inflammation in the 4T1 murine breast cancer model

This study shows that SAA1-2 proteins are not essential for systemic inflammation in the 4T1 murine breast cancer model.

Combined blockade of VEGF, Angiopoietin-2, and PD1 reprograms glioblastoma endothelial cells into quasi-antigen-presenting cells

This study shows that blocking VEGF, Ang2, and PD1 reprograms GBM endothelial cells into quasi-antigen-presenting cells, enhancing anti-tumor responses and controlling edema.

Probing the rules of cell coordination in live tissues by interpretable machine learning based on graph neural networks

The paper uses graph neural networks to infer cell coordination rules from live tissue data, revealing region-specific coordination patterns in mammalian epidermis.

A Drosophila Toolkit for Imaging of HA-tagged Proteins Unveiled a Block in Autophagy Flux in the Last Instar Larval Fat Body

Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer.

The paper shows that epidermal stem cells undergo gradual differentiation without exiting the cell cycle, generating heterogeneity in the stem cell layer.