Type-3 Secretion System-induced pyroptosis protects Pseudomonas against cell-autonomous immunity
E. Eren, R. Planes, J. M. Buyck, P.-J. Bordignon, A. Colom, O. Cunrath, R. F. Dreier, J. C. Santos, V. Duplan-Eche, E. Näser, A. Peixoto, D. Bumann, C. Cougoule, A. Coste, O. Neyrolles, , E. Meunier
This study shows that Pseudomonas aeruginosa uses its Type-3 Secretion System to induce macrophage pyroptosis, escaping immune trapping, while T3SS-deficient strains are captured by inflammasome-mediated immunity.
bioRxiv · May 28, 2019 · PreprintImmunology