O. Neyrolles

Nucleotidyltransferase toxin MenT targets and extends the aminoacyl acceptor ends of serine tRNAs in vivo to control Mycobacterium tuberculosis growth

This study identifies MenT3 as a tRNA nucleotidyltransferase that modifies serine tRNAs in Mycobacterium tuberculosis, affecting bacterial growth and revealing its role in infection.

Maintenance of cell wall remodeling and vesicle production are connected in Mycobacterium tuberculosis

This study investigates the role of VirR in Mycobacterium tuberculosis vesicle production and links it to cell wall remodeling, suggesting potential therapeutic targets.

Elevated glycolytic metabolism of monocytes limits the generation of HIF-1α-driven migratory dendritic cells in tuberculosis

This study shows that elevated glycolytic metabolism in monocytes during tuberculosis impairs their differentiation into migratory dendritic cells, limiting immune response.

Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms

The paper identifies PacL1 as a scaffold that assembles P-ATPase-containing metal efflux platforms in Mycobacterium tuberculosis, contributing to zinc resistance.

Metabolic regulation of ILC2 differentiation into ILC1-like cells during Mycobacterium tuberculosis infection

This study shows that Mycobacterium tuberculosis infection drives immature lung ILC2 to differentiate into ILC1-like cells through type 1 cytokines and a glycolytic program controlled by HIF1.

Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

This study identifies Siglec-1 as a factor induced by TB-associated IFN-I that localizes on TNTs and promotes HIV-1 spread in macrophages.

Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity

This study shows that host-derived lipids from tuberculous pleurisy reduce glycolytic activity and impair HIF-1-mediated metabolic reprogramming in macrophages, promoting Mtb infection.

Colon-specific immune microenvironment regulates cancer progression versus rejection

This study shows that the colon microenvironment influences whether colorectal tumors progress or are rejected, with distinct immune signatures in each outcome.

Mycobacterium tuberculosis Modulates the Metabolism of Alternatively Activated Macrophages to Promote Foam Cell Formation and Intracellular Survival

This study shows that Mtb modulates macrophage metabolism to promote foam cell formation and survival by altering lipid metabolism and FAO pathways.

An improved Xer-cise technology for the generation of multiple unmarked mutants in Mycobacteria

The paper improves the Xer-cise technique to generate multiple unmarked mutants in Mycobacteria by using dif site variants that prevent recombination between cassettes, enhancing genetic stability.

Type-3 Secretion System-induced pyroptosis protects Pseudomonas against cell-autonomous immunity

This study shows that Pseudomonas aeruginosa uses its Type-3 Secretion System to induce macrophage pyroptosis, escaping immune trapping, while T3SS-deficient strains are captured by inflammasome-mediated immunity.