Author

J. M. Buyck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Cougoule· 2 shared E. Meunier· 2 shared R. Planes· 2 shared A. Colom· 1 shared A. Coste· 1 shared A. Henras· 1 shared A. Hessel· 1 shared A. Peixoto· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

C. Cougoule

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2 papers

Recent·Most cited

EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption upon Pseudomonas infection

M. Pinilla, R. Mazars, R. Verge, L. Gorse, K. Santoni, K. S. Robinson, G. A. Toh, L. Prouvensier, S. A. Leonicaza, A. Hessel, d. pericat, M. Murris, A. Henras, J. M. Buyck, C. Cougoule, , E. Meunier

This paper shows that Pseudomonas aeruginosa's Exotoxin A activates the NLRP1 inflammasome via EEF2 inactivation, causing epithelial damage and pyroptosis, and identifies ZAK as a key sensor in this process.

bioRxiv · Jan 16, 2023 · PreprintImmunology

Type-3 Secretion System-induced pyroptosis protects Pseudomonas against cell-autonomous immunity

E. Eren, R. Planes, J. M. Buyck, P.-J. Bordignon, A. Colom, O. Cunrath, R. F. Dreier, J. C. Santos, V. Duplan-Eche, E. Näser, A. Peixoto, D. Bumann, C. Cougoule, A. Coste, O. Neyrolles, , E. Meunier

This study shows that Pseudomonas aeruginosa uses its Type-3 Secretion System to induce macrophage pyroptosis, escaping immune trapping, while T3SS-deficient strains are captured by inflammasome-mediated immunity.

bioRxiv · May 28, 2019 · PreprintImmunology