Author

D. Bhella

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 7 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Research Focus:protein structure prediction· 5 Approach:microscopy & imaging analysis· 3 Research Focus:cell type annotation· 2 Organism:non-human primate· 2

Frequent Co-Authors

J. Streetley· 5 shared S. Vijayakrishnan· 4 shared M. J. Conley· 3 shared M. McElwee· 3 shared C. L. Kueh· 2 shared I. G. Goodfellow· 2 shared K. L. Ho· 2 shared M. Gabrielsen· 2 shared

Activity by Year

2017-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersMicrobiology

J. Streetley

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral budding and cytopathogenicity

I. Manuelyan, A. M. Schmoker, B. L. Yount, P. Eisenhauer, J. I. Keller, C. Gold, D. Terino, C. M. Ziegler, J. Alexander, H. E. Driscoll, E. Hutchinson, D. Bhella, C. D. Syme, D. G. Widman, M. T. Heise, , J. W. Botten

This study maps host-driven post-translational modifications on the Zika virus proteome, identifies key phosphosites, and shows how an FDA-approved kinase inhibitor blocks viral growth.

bioRxiv · Nov 24, 2021 · PreprintMicrobiology

In vitro coinfection by influenza A virus and respiratory syncytial virus generates hybrid viral particles with altered structure and tropism

J. Haney, S. Vijayakrishnan, J. Streetley, K. Dee, D. Goldfarb, M. Clarke, M. Mullin, S. D. Carter, D. Bhella, P. R. Murcia

This study shows that co-infection of human lung cells with influenza A and respiratory syncytial viruses produces hybrid viral particles with altered structure and immune evasion capabilities.

bioRxiv · Aug 16, 2021 · PreprintMicrobiology

Helical Ordering of Envelope Associated Proteins and Glycoproteins in Respiratory Syncytial Virus Filamentous Virions

M. J. Conley, J. M. Short, J. Hutchings, A. M. Burns, J. Streetley, S. E. Bakker, H. Jaffery, M. Stewart, B. J. Power, G. Zanetti, R. Fearns, S. Vijayakrishnan, D. Bhella

This study uses cryoEM and cryoET to reveal helical symmetry in RSV virions, showing how M proteins and glycoproteins are organized and their implications for vaccine targets.

bioRxiv · Aug 4, 2021Microbiology

The cryo-EM structure of vesivirus 2117 highlights functional variations in entry pathways for viruses in different clades of the vesivirus genus.

H. Sutherland, M. J. Conley, E. Emmott, J. Streetley, I. G. Goodfellow, D. Bhella

This study determines the cryo-EM structure of vesivirus 2117, revealing structural differences in the capsid that suggest variations in entry pathways among vesivirus clades.

bioRxiv · Feb 5, 2021Microbiology

Higher-order structures of the foot-and-mouth disease virus RNA-dependent RNA polymerase required for dynamic inter-molecular interactions involved in viral genome replication

E. A. Loundras, J. Streetley, M. R. Herod, R. F. Thompson, M. Harris, D. Bhella, N. J. Stonehouse

This study identifies higher-order structures of the foot-and-mouth disease virus RdRp and their role in RNA replication through cryo-EM and mutagenesis.

bioRxiv · Dec 17, 2020 · PreprintMicrobiology

In situ structure determination of virus capsids imaged within cell nuclei by correlative light and cryo-electron tomography.

S. Vijayakrishnan, M. McElwee, C. Loney, F. J. Rixon, D. Bhella

The paper determines the structure of herpesvirus capsids within cell nuclei using cryo-ET and sub-tomogram averaging, revealing the presence of the tegument complex before nuclear egress.

bioRxiv · Feb 6, 2020Biophysics

Calicivirus VP2 forms a portal to mediate endosome escape

M. J. Conley, M. McElwee, L. B. Azmi, M. Gabrielsen, O. Byron, I. G. Goodfellow, D. Bhella

This paper identifies VP2 as a portal structure in caliciviruses that facilitates endosome escape, revealing its role in viral genome release.

bioRxiv · Aug 23, 2018Microbiology

Structure of the Macrobrachium rosenbergii Nodavirus: A new genus within the Nodaviridae?

K. L. Ho, M. Gabrielsen, P. L. Beh, C. L. Kueh, T. Qiu Xian, J. Streetley, W. S. Tan, D. Bhella

This paper presents the atomic-resolution structure of Macrobrachium rosenbergii nodavirus (MrNV) using cryoEM, revealing a unique T=3 capsid with dimeric spikes and structural similarities to Tombusviridae, challenging its taxonomic classification.

bioRxiv · Aug 7, 2018Microbiology

Structure of the herpes-simplex virus portal-vertex

M. McElwee, S. Vijayakrishnan, F. Rixon, D. Bhella

This study determines the structure of the herpes simplex virus portal-vertex at sub-nanometer resolution using cryoEM, revealing new features and genome packaging mechanisms.

bioRxiv · Mar 28, 2018Microbiology

Cryo-Electron Microscopy Structure of the Macrobrachium Rosenbergii Nodavirus Capsid at 7 Angstroms Resolution

K. L. Ho, C. L. Kueh, P. L. Beh, W. S. Tan, D. Bhella

The paper determines the 7 angstrom resolution cryo-EM structure of MrNV VLPs, revealing a novel capsid organization distinct from other nodaviruses.

bioRxiv · Jan 26, 2017Microbiology