Pathogenic mutations in LRRK2 sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
A. Mamais, N. Landeck, R. G. Langston, L. Bonet-Ponce, N. Smith, A. Beilina, A. Kaganovich, M. C. Ghosh, L. Pellegrini, J. H. Kluss, R. Kumaran, I. Papazoglou, N. Maio, C. Kim, D. C. Gershlick, M. R. Cookson
This study shows that LRRK2 mutations sequester Rab8a into lysosomes and disrupt transferrin-mediated iron uptake in microglia, linking LRRK2 dysfunction to iron dysregulation in Parkinson's disease.
bioRxiv · Jul 27, 2020 · PreprintCell Biology