M. R. Cookson

Opposing actions of JIP4 and RILPL1 provide antagonistic motor force to dynamically regulate membrane reformation during lysosomal tubulation/sorting driven by LRRK2

The paper identifies JIP4 and RILPL1 as opposing motor adaptors regulating lysosomal tubulation through differential microtubule transport.

Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling

The paper evaluates CNVs in a hiPSC line and concludes that their potential impact on neurological disease modelling is outweighed by the line's benefits.

DJ-1 glyoxalase activity makes a modest contribution to cellular defense against methylglyoxal damage in neurons

This study investigates DJ-1's role in glycation defense and finds it has only a minor effect on reducing methylglyoxal damage in neurons.

Combined knockout of Lrrk2 and Rab29 does not result in behavioral abnormalities in vivo

This study shows that double knockout of Lrrk2 and Rab29 in mice does not lead to significant behavioral or dopamine neuron loss, suggesting the pathway can be safely targeted therapeutically.

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2-positive lysosomes

This study shows that lysosomal positioning regulates LRRK2-dependent Rab10 phosphorylation, with phosphatase activity modulating this process in perinuclear lysosomes.

Pathogenic mutations in LRRK2 sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia

This study shows that LRRK2 mutations sequester Rab8a into lysosomes and disrupt transferrin-mediated iron uptake in microglia, linking LRRK2 dysfunction to iron dysregulation in Parkinson's disease.

Mutations in the SPTLC1 gene are a cause of juvenile amyotrophic lateral sclerosis that may be amenable to serine supplementation

The paper identifies de-novo SPTLC1 mutations in juvenile ALS patients and suggests serine supplementation may alleviate symptoms.

LRRK2 mediates tubulation and vesicle sorting from membrane damaged lysosomes

This study identifies LRRK2's role in lysosomal tubulation and vesicle sorting from damaged lysosomes, introducing the process LYTL.

A revised 1.6 Å structure of the GTPase domain of the Parkinson’s disease-associated protein LRRK2 provides insights into mechanisms

This paper reports a 1.6 Å crystal structure of the GTPase domain of LRRK2, revealing how PD-associated mutations at Arg-1441 impair nucleotide-dependent conformational dynamics.