Author

J. H. Kluss

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Beilina· 4 shared L. Bonet-Ponce· 4 shared M. R. Cookson· 4 shared A. Mamais· 2 shared N. Landeck· 2 shared R. Kumaran· 2 shared Y. Li· 2 shared A. Kaganovich· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCell Biology

A. Beilina

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Opposing actions of JIP4 and RILPL1 provide antagonistic motor force to dynamically regulate membrane reformation during lysosomal tubulation/sorting driven by LRRK2

L. Bonet-Ponce, T. Tegicho, A. Beilina, J. H. Kluss, Y. Li, M. R. Cookson

The paper identifies JIP4 and RILPL1 as opposing motor adaptors regulating lysosomal tubulation through differential microtubule transport.

bioRxiv · Apr 2, 2024 · PreprintCell Biology

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2-positive lysosomes

J. H. Kluss, A. Beilina, C. D. Williamson, P. A. Lewis, M. R. Cookson, L. Bonet-Ponce

This study shows that lysosomal positioning regulates LRRK2-dependent Rab10 phosphorylation, with phosphatase activity modulating this process in perinuclear lysosomes.

bioRxiv · Dec 1, 2020 · PreprintCell Biology

Pathogenic mutations in LRRK2 sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia

A. Mamais, N. Landeck, R. G. Langston, L. Bonet-Ponce, N. Smith, A. Beilina, A. Kaganovich, M. C. Ghosh, L. Pellegrini, J. H. Kluss, R. Kumaran, I. Papazoglou, N. Maio, C. Kim, D. C. Gershlick, M. R. Cookson

This study shows that LRRK2 mutations sequester Rab8a into lysosomes and disrupt transferrin-mediated iron uptake in microglia, linking LRRK2 dysfunction to iron dysregulation in Parkinson's disease.

bioRxiv · Jul 27, 2020 · PreprintCell Biology

LRRK2 mediates tubulation and vesicle sorting from membrane damaged lysosomes

L. Bonet-Ponce, A. Beilina, C. Williamson, E. Lindberg, J. H. Kluss, S. Saez-Atienzar, N. Landeck, R. Kumaran, A. Mamais, C. K. E. Bleck, Y. Li, M. R. Cookson

This study identifies LRRK2's role in lysosomal tubulation and vesicle sorting from damaged lysosomes, introducing the process LYTL.

bioRxiv · Jan 23, 2020Cell Biology