A. Beilina

Opposing actions of JIP4 and RILPL1 provide antagonistic motor force to dynamically regulate membrane reformation during lysosomal tubulation/sorting driven by LRRK2

The paper identifies JIP4 and RILPL1 as opposing motor adaptors regulating lysosomal tubulation through differential microtubule transport.

Combined knockout of Lrrk2 and Rab29 does not result in behavioral abnormalities in vivo

This study shows that double knockout of Lrrk2 and Rab29 in mice does not lead to significant behavioral or dopamine neuron loss, suggesting the pathway can be safely targeted therapeutically.

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2-positive lysosomes

This study shows that lysosomal positioning regulates LRRK2-dependent Rab10 phosphorylation, with phosphatase activity modulating this process in perinuclear lysosomes.

Pathogenic mutations in LRRK2 sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia

This study shows that LRRK2 mutations sequester Rab8a into lysosomes and disrupt transferrin-mediated iron uptake in microglia, linking LRRK2 dysfunction to iron dysregulation in Parkinson's disease.

LRRK2 mediates tubulation and vesicle sorting from membrane damaged lysosomes

This study identifies LRRK2's role in lysosomal tubulation and vesicle sorting from damaged lysosomes, introducing the process LYTL.