Author

R. Kumaran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Beilina· 2 shared A. Mamais· 2 shared J. H. Kluss· 2 shared L. Bonet-Ponce· 2 shared M. R. Cookson· 2 shared N. Landeck· 2 shared A. J. M. Crowe· 1 shared A. Kaganovich· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

A. Beilina

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Journey to the center of the phage; revealing the ejectosome of Pectobacterium bacteriophage {Phi}M1

A.-R. Eruera, J. Hodgkinson-Bean, G. L. Rutter, F. R. Hills, R. Kumaran, A. J. M. Crowe, N. Jadav, K. L. McJarrow-Keller, F. E. Jorge, J. Hyun, H. Kim, B. Ryu, M. Bostina

This paper determines the cryo-EM structure of the ejectosome of bacteriophage {Phi}M1, revealing unique structural features and a novel DNA spooling mechanism.

bioRxiv · Feb 19, 2024 · PreprintMicrobiology

Pathogenic mutations in LRRK2 sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia

A. Mamais, N. Landeck, R. G. Langston, L. Bonet-Ponce, N. Smith, A. Beilina, A. Kaganovich, M. C. Ghosh, L. Pellegrini, J. H. Kluss, R. Kumaran, I. Papazoglou, N. Maio, C. Kim, D. C. Gershlick, M. R. Cookson

This study shows that LRRK2 mutations sequester Rab8a into lysosomes and disrupt transferrin-mediated iron uptake in microglia, linking LRRK2 dysfunction to iron dysregulation in Parkinson's disease.

bioRxiv · Jul 27, 2020 · PreprintCell Biology

LRRK2 mediates tubulation and vesicle sorting from membrane damaged lysosomes

L. Bonet-Ponce, A. Beilina, C. Williamson, E. Lindberg, J. H. Kluss, S. Saez-Atienzar, N. Landeck, R. Kumaran, A. Mamais, C. K. E. Bleck, Y. Li, M. R. Cookson

This study identifies LRRK2's role in lysosomal tubulation and vesicle sorting from damaged lysosomes, introducing the process LYTL.

bioRxiv · Jan 23, 2020Cell Biology