Cancer BiologybioRxivPreprint
Cancer cells are sensitive to wild-type IDH1 inhibition under nutrient limitation
A. Vaziri-Gohar, J. J. Hue, H. J. Graor…·J. M. Winter
This study shows that wild-type IDH1 is a metabolic target in pancreatic cancer cells under nutrient limitation, and FDA-approved drugs can inhibit it effectively in preclinical models.