Author

A. Vaziri-Gohar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 6

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:human· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Zarei· 5 shared H. J. Graor· 4 shared J. J. Hue· 4 shared J. M. Winter· 4 shared M. Rathore· 4 shared R. Wang· 4 shared O. Hajihassani· 3 shared A. Abbas· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCancer Biology

M. Zarei

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Surgical techniques and tips for a reliable murine model of primary and metastatic pancreatic cancer

J. J. Hue, M. Zarei, H. J. Graor, O. Hajihassani, E. S. Katayama, A. W. Loftus, A. Vaziri-Gohar, J. M. Winter

The paper provides detailed surgical techniques for orthotopic and splenic injections in a murine model of pancreatic cancer to improve preclinical research accuracy.

bioRxiv · Jul 30, 2022 · PreprintCancer Biology

Liver Endothelium Microenvironment Promotes HER3-mediated Cell Growth in Pancreatic ductal adenocarcinoma

W. Zhang, M. Wright, M. Rathore, M. Zarei, A. Vaziri-Gohar, J. Winter, J. Brody, R. Wang

This study shows liver endothelial cells promote PDAC growth via HER3-AKT signaling, suggesting HER3-targeted therapies for HER3-positive metastatic PDAC.

bioRxiv · Jun 24, 2022 · PreprintCancer Biology

Wild-type IDH1 inhibition enhances chemotherapy response in melanoma

M. Zarei, O. Hajihassani, J. J. Hue, H. J. Graor, M. Rathore, A. Vaziri-Gohar, J. M. Asara, J. M. Winter, L. D. Rothermel

This study shows that inhibiting wild-type IDH1 enhances chemotherapy response in melanoma by reducing redox homeostasis and increasing reactive oxygen species.

bioRxiv · May 13, 2022Cancer Biology

Increased glucose availability sensitizes pancreatic cancer to chemotherapy

A. Vaziri-Gohar, J. J. Hue, H. J. Graor, A. Abbas, M. Zarei, O. Hajihassani, G. Titomihelakis, J. Feczko, M. Rathore, R. Wang, M. Zarei, M. Goudarzi, R. Zhang, B. Willard, L. Zhang, , J. M. Winter

This study shows that high glucose levels increase the effectiveness of chemotherapy in pancreatic cancer by reducing glutathione biosynthesis, which enhances oxidative stress in cancer cells.

bioRxiv · Apr 29, 2022Cancer Biology

Liver Endothelium Promotes HER3-mediated Cell Survival in KRAS Wild-type and Mutant Colorectal Cancer Cells

M. Rathore, M. Wright, R. Bhattacharya, F. Fan, A. Vaziri-Gohar, J. Winter, Z. Wang, S. Markowitz, J. Willis, L. Ellis, R. Wang

The paper shows liver endothelial cells promote HER3-mediated survival in KRAS wild-type and mutant colorectal cancer cells through secreted factors, suggesting HER3 as a therapeutic target regardless of KRAS mutation status.

bioRxiv · Apr 27, 2021 · PreprintCancer Biology

Cancer cells are sensitive to wild-type IDH1 inhibition under nutrient limitation

A. Vaziri-Gohar, J. J. Hue, H. J. Graor, E. Prendergast, V. Chen, J. Cassel, F. S. Mohammed, A. Abbas, K. Dukleska, I. Khokhar, O. Hajhassani, M. Zarei, R. Wang, L. D. Rothermel, I. Bederman, , J. M. Winter

This study shows that wild-type IDH1 is a metabolic target in pancreatic cancer cells under nutrient limitation, and FDA-approved drugs can inhibit it effectively in preclinical models.

bioRxiv · Nov 19, 2020 · PreprintCancer Biology