Author

H. J. Graor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. J. Hue· 5 shared J. M. Winter· 5 shared M. Zarei· 5 shared A. Vaziri-Gohar· 4 shared O. Hajihassani· 4 shared L. D. Rothermel· 3 shared A. Abbas· 2 shared H. Brunengraber· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

J. J. Hue

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5 papers

Recent·Most cited

Targeting wild-type IDH1 enhances chemosensitivity in pancreatic cancer

M. Zarei, O. Hajihassani, J. J. Hue, H. J. Graor, L. D. Rothermel, J. M. Winter

This study shows that targeting wild-type IDH1 enhances chemosensitivity in pancreatic cancer by disrupting redox balance and increasing ROS-induced apoptosis.

bioRxiv · Mar 29, 2023Cancer Biology

Surgical techniques and tips for a reliable murine model of primary and metastatic pancreatic cancer

J. J. Hue, M. Zarei, H. J. Graor, O. Hajihassani, E. S. Katayama, A. W. Loftus, A. Vaziri-Gohar, J. M. Winter

The paper provides detailed surgical techniques for orthotopic and splenic injections in a murine model of pancreatic cancer to improve preclinical research accuracy.

bioRxiv · Jul 30, 2022 · PreprintCancer Biology

Wild-type IDH1 inhibition enhances chemotherapy response in melanoma

M. Zarei, O. Hajihassani, J. J. Hue, H. J. Graor, M. Rathore, A. Vaziri-Gohar, J. M. Asara, J. M. Winter, L. D. Rothermel

This study shows that inhibiting wild-type IDH1 enhances chemotherapy response in melanoma by reducing redox homeostasis and increasing reactive oxygen species.

bioRxiv · May 13, 2022Cancer Biology

Increased glucose availability sensitizes pancreatic cancer to chemotherapy

A. Vaziri-Gohar, J. J. Hue, H. J. Graor, A. Abbas, M. Zarei, O. Hajihassani, G. Titomihelakis, J. Feczko, M. Rathore, R. Wang, M. Zarei, M. Goudarzi, R. Zhang, B. Willard, L. Zhang, , J. M. Winter

This study shows that high glucose levels increase the effectiveness of chemotherapy in pancreatic cancer by reducing glutathione biosynthesis, which enhances oxidative stress in cancer cells.

bioRxiv · Apr 29, 2022Cancer Biology

Cancer cells are sensitive to wild-type IDH1 inhibition under nutrient limitation

A. Vaziri-Gohar, J. J. Hue, H. J. Graor, E. Prendergast, V. Chen, J. Cassel, F. S. Mohammed, A. Abbas, K. Dukleska, I. Khokhar, O. Hajhassani, M. Zarei, R. Wang, L. D. Rothermel, I. Bederman, , J. M. Winter

This study shows that wild-type IDH1 is a metabolic target in pancreatic cancer cells under nutrient limitation, and FDA-approved drugs can inhibit it effectively in preclinical models.

bioRxiv · Nov 19, 2020 · PreprintCancer Biology