Author

R. Ghose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Ganez-Zapater· 3 shared S. Sdelci· 3 shared F. Pezzano· 2 shared L. Espinar· 2 shared N. Pardo-Lorente· 2 shared S. Das· 2 shared S. Kourtis· 2 shared U. Ghose· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

A. Ganez-Zapater

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects

R. Ghose, F. Pezzano, S. Kourtis, I. Sheraj, S. Das, A. Ganez-Zapater, U. Ghose, L. Espinar, K. Parapatics, V. Venturini, A. C. Muller, V. Ruprecht, S. Sdelci

This study shows that mechanical confinement causes mitochondria to relocate to the nucleus, leading to a nuclear ATP surge that supports DNA repair and cell cycle progression.

bioRxiv · Dec 20, 2023Cell Biology

Comprehensive chromatome profiling identifies metabolic enzymes on chromatin in healthy and cancer cells

S. Kourtis, M. Guirola, N. Pardo-Lorente, R. Ghose, M. Garcia-Cao, A. Ganez-Zapater, S. Haynes, F. Fontaine, A. Muller, S. Sdelci

The paper identifies widespread metabolic enzyme localization on chromatin in healthy and cancer cells, showing tissue-specific abundance and non-canonical roles in DNA damage and repair.

bioRxiv · Dec 6, 2023 · PreprintCancer Biology

Adaptation to ARF6-depletion in KRAS-driven PDAC is abolished by targeting TLR2

R. Ghose, S. Das, J. Urgel-Solas, F. Pezzano, D. Datta, U. Ghose, A. Ganez-Zapater, N. Pardo-Lorente, L. Espinar, L. Garcia, C. Cannata, V. Ruprecht, A. Janic, S. Sdelci

This study identifies TLR2 as a target to counteract adaptation to ARF6 depletion in KRAS-driven PDAC, reducing proliferation, migration, and invasion.

bioRxiv · Nov 30, 2023 · PreprintCancer Biology

Conserved Link between Catalytic Site Interactions and Global Conformation in P-loop Enzymes

F. Hajredini, R. Ghose

The paper analyzes P-loop enzyme structures to show that global conformational states correlate with catalytic site geometry, revealing conserved Mg2+ coordination in closed states and disrupted coordination in open states.

bioRxiv · Jul 13, 2022 · PreprintBiochemistry

Structural Basis for the Calmodulin-Mediated Activation of eEF-2K

A. Piserchio, E. A. Isiroho, K. Long, A. L. Bohanon, E. A. Kumar, N. Will, D. Jeruzalmi, K. N. Dalby, R. Ghose

The paper determines the atomic structure of the calmodulin-eEF-2KTR complex, revealing the mechanism by which calmodulin activates eEF-2K through an allosteric spine.

bioRxiv · Jan 15, 2022 · PreprintBiochemistry